Send to quote
Cart (0)
Quality Certyficate street: Kolejowa 2, 30-805 Cracow
OpenMedis - Anatomial Models

Pedunculated Adenoma of the Colon

Product code: AM02782

Product description: Pedunculated Adenoma of the Colon

Clinical History 

A 50-year old male underwent a colonoscopy after testing positive for faecal occult blood during a screening test. Colonoscopy revealed a pedunculated tumour in the descending colon, which was later resected. 

 

Pathology 

This specimen is the resected segment of descending colon. There is a single dark lobulated mass visible arising from the mucosal surface. It is attached to a stalk which is 4cm in length. Histologically, the mass comprises a core of connective tissue covered with hyperplastic glandular epithelium of colonic type, with focal nuclear atypia. This is an example of a tubular colonic adenoma.

 

Further Information 

Colorectal adenomas are intraepithelial neoplasms that characteristically display epithelial dysplasia. They are benign but are precursors to adenocarcinoma. Not all adenomas evolve into adenocarcinoma. They produce polyps (sometimes pedunculated) or sessile lesions or variable size. They occur predominantly in males and are more common in Western countries due to diet and lifestyle. They are present in about 30% of people over the age of 60 years in the West. There is an increased risk in patients with a positive family history of colorectal adenocarcinoma. Regular surveillance colonoscopy in at risk groups with polyp removal reduces incidence of adenocarcinoma. There are three classifications of colonic adenomas based on their architecture: tubular (>75% have a tubular morphology), tubulovillous (25-75% villous morphology) and villous (>75% have villous morphology). Histologically, they may have epithelial dysplasia characterized by nuclear hyperchromasia, elongation and stratification. Tubular adenomas tend to be small, pedunculated polys composed of rounded or tubular glands. Pedunculated adenomas have a slender fibromuscular stalk with blood vessels derived from the submucosa. The stalk is usually non-neoplastic epithelium. The size of the adenoma is the biggest predictor of progression to adenocarcinoma. Progression is rare in adenomas <1cm in diameter. However, up to 40% of lesions larger than 4cm in diameter progress to adenocarcinoma. Most adenomas are asymptomatic and slow growing. Large polyps may present with symptoms of anaemia from occult bleeding. Villous adenomas occasionally secrete large amounts of mucoid protein and/or potassium rich fluid, leading possibly to hypokalemia.

Inquiry

Your chosen product: Pedunculated Adenoma of the Colon
Name and surname:
Phone number:
E-mail adress:
Message:
I consent to the processing of my personal data within the meaning of the Act of 10 May 2018 on the Protection of Personal Data and the Act of 16 July 2004 Telecommunications Law for marketing purposes by OpenMedis and OpenMedis Sp. z o.o and I declare that the provision of my personal data is voluntary and that I have been informed about the right to request access to my personal data, change and delete it.

Related products

Openmedis - recommended categories